ESTRATIOL DEPENDENT MOLECULAR AND BIOCHEMICAL CHANGE IN HUMAN STERMATOZA

Abstract

In organotypic hippocampal slice cultures, reducing A-type K1 current (IA) increases NMDAR-mediated EPSCs with no effect on AMPAR-mediated EPSCs (Jung et al., 2008). Interestingly, this effect is specific for NR2Bcontaining NMDARs. E2 is known to modulate K1 channels in several brain regions (Nabekura et al., 1986; Minami et al., 1990). In the hypothalamus, 1 week of E2 treatment reduced the current density of IA in an ERdependent manner (DeFazio and Moenter, 2002). If E2 acts similarly in the hippocampus, a reduction in IA might account for the observed increase in NR2B-dependent NMDAR EPSCs in a way that would not require changes in expression levels or phosphorylation.